Cancer is a genetic disease that is caused by mutations in oncogenes, tumor suppressor
genes and stability genes. The fact that the metabolism of tumor cells is altered has been …

Epigenetics acts as an interface between environmental/exogenous factors, cellular
responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of …

Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are
significantly upregulated and activated in many cancers and portend poor prognosis. Even …

Background A number of constitutively activated signaling pathways play critical roles in the
survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT …

Human fatty acid synthase (FASN) is a 270-kDa cytosolic dimeric enzyme that is responsible
for palmitate synthesis. FASN is slowly emerging and rediscovered as a marker for …

To identify genes potentially playing an important role in the progression of colorectal
carcinoma (CRC), we screened global gene expression using cDNA expression array on 41 …

366 Editorial| JNCI Vol. 102, Issue 6| March 17, 2010 can be a source of selection bias. The
potential for bias will vary by many factors that may affect availability of tissue. Molecular …

Alterations in the Wnt/β‐catenin pathway define a key event in the pathogenesis of colon
cancer. We have recently shown that CDK8, the gene encoding a cyclin‐dependent kinase …

Purpose There is a growing body of evidence suggesting a decisive involvement of the
human lipid metabolism in cancer development. However, clinical data on the association …

Cellular growth is highly dependent on sustained production of lipids. Sterol composition of
cellular membranes determines multiple biochemical and biophysical properties of …