Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Gas-solid fluidized beds have drawn the attention of engineers and researchers as an
effective technology for a large variety of applications, and numerical simulations can play …

Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

Fluid–solid systems play a major role in a wide variety of industries, from pharmaceutical
and consumer goods to chemical plants and energy generation. Along with this variety of …

Population balance models are tools for the study of dispersed systems, such as granular
materials, polymers, colloids and aerosols. They are applied with increasing frequency …

Since the past several decades, poor water solubility of existing and new drugs in the
pipeline have remained a challenging issue for the pharmaceutical industry. Literature …

The computational cost of the discrete element method (DEM)-population balance model
(PBM) coupled framework is predominantly attributed to DEM simulations. To overcome this …

The implementation of continuous pharmaceutical manufacturing requires advanced control
strategies rather than traditional end product testing or an operation within a small range of …

Granulation plays an important role in various manufacturing sectors, including the
chemical, pharmaceutical, and agricultural sectors. Computer simulation by coupling a …

This paper presents surrogate models of dissolution behavior to identify the critical input
parameters in tablet manufacturing processes. Dissolution behavior is a critical quality …