LEA proteins during water stress: not just for plants anymore
Late embryogenesis abundant (LEA) proteins are extremely hydrophilic proteins that were
first identified in land plants. Intracellular accumulation is tightly correlated with acquisition of …
first identified in land plants. Intracellular accumulation is tightly correlated with acquisition of …
[HTML][HTML] The biology of tardigrade disordered proteins in extreme stress tolerance
C Hesgrove, TC Boothby - Cell Communication and Signaling, 2020 - Springer
Disordered proteins have long been known to help mediate tolerance to different abiotic
stresses including freezing, osmotic stress, high temperatures, and desiccation in a diverse …
stresses including freezing, osmotic stress, high temperatures, and desiccation in a diverse …
[HTML][HTML] Tardigrades use intrinsically disordered proteins to survive desiccation
Tardigrades are microscopic animals that survive a remarkable array of stresses, including
desiccation. How tardigrades survive desiccation has remained a mystery for more than 250 …
desiccation. How tardigrades survive desiccation has remained a mystery for more than 250 …
[HTML][HTML] Long-term storage of lipid-like nanoparticles for mRNA delivery
Lipid-like nanoparticles (LLNs) have been extensively explored for messenger RNA (mRNA)
delivery in various biomedical applications. However, the long-term storage of these …
delivery in various biomedical applications. However, the long-term storage of these …
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
RL Ball, P Bajaj, KA Whitehead - International journal of …, 2017 - Taylor & Francis
The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …
delivery systems that maintain stability and potency for long times under ambient conditions …
[HTML][HTML] Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus
Tardigrada, a phylum of meiofaunal organisms, have been at the center of discussions of the
evolution of Metazoa, the biology of survival in extreme environments, and the role of …
evolution of Metazoa, the biology of survival in extreme environments, and the role of …
[HTML][HTML] Trehalose and tardigrade CAHS proteins work synergistically to promote desiccation tolerance
Tardigrades are microscopic animals renowned for their ability to survive extreme
desiccation. Unlike many desiccation-tolerant organisms that accumulate high levels of the …
desiccation. Unlike many desiccation-tolerant organisms that accumulate high levels of the …
How sugars protect dry protein structure
JA Brom, RG Petrikis, GJ Pielak - Biochemistry, 2023 - ACS Publications
Extremotolerant organisms and industry exploit sugars as desiccation protectants, with
trehalose being widely used by both. How sugars, in general, and the hydrolytically stable …
trehalose being widely used by both. How sugars, in general, and the hydrolytically stable …
[HTML][HTML] Stress-dependent cell stiffening by tardigrade tolerance proteins that reversibly form a filamentous network and gel
A Tanaka, T Nakano, K Watanabe, K Masuda… - PLoS …, 2022 - journals.plos.org
Tardigrades are able to tolerate almost complete dehydration by entering a reversible
ametabolic state called anhydrobiosis and resume their animation upon rehydration …
ametabolic state called anhydrobiosis and resume their animation upon rehydration …
[HTML][HTML] Mechanisms of desiccation tolerance: themes and variations in brine shrimp, roundworms, and tardigrades
JD Hibshman, JS Clegg, B Goldstein - Frontiers in Physiology, 2020 - frontiersin.org
Water is critical for the survival of most cells and organisms. Remarkably, a small number of
multicellular animals are able to survive nearly complete drying. The phenomenon of …
multicellular animals are able to survive nearly complete drying. The phenomenon of …