Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to
inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific …

Proteins are ordered useful cellular entities, required for normal health and organism's
survival. The proteome is the absolute set of cellular expressed proteins, which regulates a …

All cells rely on highly conserved protein folding and clearance pathways to detect and
resolve protein damage and to maintain protein homeostasis (proteostasis). Because age is …

Objective Levels of S100A8/A9, a proinflammatory and prothrombotic protein complex, are
increased in several diseases, and high levels predispose to cardiovascular disease (CVD) …

Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to
Alzheimer's disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor …

Quantitative kinetic analysis is critical for understanding amyloid mechanisms. Here we
demonstrate the application of generic Finke–Watzky (FW) two-step nucleation–autocatalytic …

Polyphenolic compounds in the Mediterranean diet have received increasing attention due
to their protective properties in amyloid neurodegenerative and many other diseases. Here …

Calcium-binding S100A8 and S100A9 proteins play a significant role in various disorders
due to their pro-inflammatory functions. Substantially, they are also relevant in …

Background Monogenic gain-of-function protein aggregation diseases, including
Huntington's disease, exhibit substantial variability in age of onset, penetrance, and clinical …