Potential dual role of KGF/KGFR as a target option in novel therapeutic strategies for the treatment of cancers and mucosal damages

S Ceccarelli, F Romano, A Angeloni… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Keratinocyte growth factor (KGF) and its receptor KGFR play a pivotal role in
regulating cell proliferation, migration, differentiation and survival, in response to injury and …

Regio-and stereoselective synthesis of diverse 3, 4-dihydro-2-quinolones through catalytic hydrative cyclization of imine-and carbonyl-ynamides with water

BH Zhu, YQ Zhang, HJ Xu, L Li, GC Deng… - ACS …, 2021 - ACS Publications
Transition-metal-catalyzed alkyne hydration reaction has attracted considerable interest in
the past decades because this approach would lead to the facile and efficient formation of …

One‐Pot Assembly of Fused Heterocycles via Oxidative Palladium‐Catalyzed Cyclization of Arylols and Iodoarenes

F Hong, Y Chen, B Lu, J Cheng - Advanced Synthesis & …, 2016 - Wiley Online Library
A one‐pot, two‐step cyclization reaction of iodoarenes with diversified arylols, including 4‐
hydroxyquinoline, quinolinone, 4‐hydroxypyridine and phenol, has been developed. By …

Metal-free ring expansion of indoles with nitroalkenes: a simple, modular approach to 3-substituted 2-quinolones

AV Aksenov, AN Smirnov, NA Aksenov, IV Aksenova… - RSC Advances, 2015 - pubs.rsc.org
3-Substituted 2-quinolones are obtained via a novel metal-free transannulation reaction of 2-
nitroolefins with 2-substituted indoles in polyphosphoric acid. This acid-mediated cascade …

The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer

X Mao, C Gauche, MWH Coughtrie, C Bui, S Gulberti… - Oncogene, 2016 - nature.com
Heparan sulfate (HS) proteoglycan chains are key components of the breast tumor
microenvironment that critically influence the behavior of cancer cells. It is established that …

Keratinocyte growth factor-2 is protective in lipopolysaccharide-induced acute lung injury in rats

L Tong, J Bi, X Zhu, G Wang, J Liu, L Rong… - Respiratory Physiology …, 2014 - Elsevier
Abstract Keratinocyte growth factor-2 (KGF-2) plays a key role in lung development, but its
role in acute lung injury has not been well characterized. Lipopolysaccharide instillation …

Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1, 2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APCMin/+ mice

G Pathuri, Q Li, A Mohammed, H Gali, JT Pento… - Bioorganic & medicinal …, 2014 - Elsevier
A selective KGFR tyrosine kinase inhibitor, N-ethylamino-2-oxo-1, 2-dihydro-quinoline-3-
carboxamide, was synthesized and its possible inhibitory effects on the development of …

A Mild and Metal Free Effective Route for the Synthesis of the Benzofuro[3,2‐c]quinoline Frame Work via Pictet‐Spengler Reaction

A Vanga, M Subbarao, C Debbarma, M Nayak… - …, 2024 - Wiley Online Library
We have reported an effective, metal free, one‐pot methodology for synthesising benzofuro
[3, 2‐c] quinolines via a Pictet‐Spengler reaction under mild conditions in open air. Our …

AhR‑E2F1‑KGFR signaling is involved in KGF‑induced intestinal epithelial cell proliferation

K Yang, J Yin, B Sheng, Q Wang… - Molecular …, 2017 - spandidos-publications.com
Keratinocyte growth factor (KGF) stimulates intestinal epithelial cell proliferation upon
binding to the KGF receptor (KGFR). The activated aryl hydrocarbon receptor (AhR) serves …

[PDF][PDF] 角质细胞生长因子(KGF) 研究进展

李云, 吴再峰, 张健, 蒋淑婉, 陈鹤 - 现代生物医学进展, 2014 - biomed.cnjournals.com
角质细胞生长因子(KGF) 属于成纤维细胞生长因子(FGFs) 家族的成员之一, 又称FGF 一7,
最早由Rubin 等(1980) 从人类胎肺成纤维细胞培养液中分离提纯获得的. 人KGF 的cDNA …