Epithelial to mesenchymal transition (EMT) is a cellular process in which cells composing
epithelial tissue lose requirements for physical contact with neighboring cells and acquire …

Metastasis is the major cause of cancer-related deaths; therefore, the prevention and
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …

Background Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal
dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Cancers develop in complex tissue environments, which they depend on for sustained
growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor …

Metastasis has intrigued researchers for more than 100 years. Despite the development of
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …

Primary tumors are known to constantly shed a large number of cancer cells into systemic
dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases …

Breast cancer is a heterogeneous disease in terms of histology, therapeutic response,
dissemination patterns to distant sites, and patient outcomes. Global gene expression …

Transitions between epithelial and mesenchymal states have crucial roles in embryonic
development. Emerging data suggest a role for these processes in regulating cellular …