Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in
heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes …

Background Cases in which a male patient receives a heart from a female donor provide an
unusual opportunity to test whether primitive cells translocate from the recipient to the graft …

Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …

Muscle injury induces strong changes in muscle cells and extracellular matrix. Muscle
regeneration after injury has similarities to muscle development during embryogenesis and …

Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in
muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a …

Although somatic stem cells have been reported to exist in various adult organs, there have
been few reports concerning stem cells in the heart. We here demonstrate that Sca-1 …

Preclinical or clinical trials for muscular dystrophies have met with modest success, mainly
because of inefficient delivery of viral vectors or donor cells to dystrophic muscles. We report …

We assessed viable Pax7−/− mice in 129Sv/J background and observed reduced growth
and marked muscle wasting together with a complete absence of functional satellite cells …