The role of hepatokines in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …
but it is also an important cause of insulin resistance and major non-communicable diseases …
The impact of insulin resistance on the kidney and vasculature
F Artunc, E Schleicher, C Weigert, A Fritsche… - Nature Reviews …, 2016 - nature.com
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …
pathways. The disorder is characterized by a reduced action of insulin despite increased …
Inflammation–nature's way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases
Siloed or singular system approach to disease management is common practice,
developing out of traditional medical school education. Textbooks of medicine describe a …
developing out of traditional medical school education. Textbooks of medicine describe a …
The role of hepatokines in metabolism
The liver is known to be involved in the natural history of the ongoing epidemics of type 2
diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased …
diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased …
Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
NF Schwenzer, F Springer, C Schraml, N Stefan… - Journal of …, 2009 - Elsevier
Hepatic steatosis is the most prevalent liver disorder in the developed world. It is closely
associated with features of metabolic syndrome, especially insulin resistance and obesity …
associated with features of metabolic syndrome, especially insulin resistance and obesity …
Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines
KJ Oh, DS Lee, WK Kim, BS Han, SC Lee… - International journal of …, 2016 - mdpi.com
Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A
high caloric intake combined with a sedentary lifestyle is the leading cause of these …
high caloric intake combined with a sedentary lifestyle is the leading cause of these …
Causes and metabolic consequences of fatty liver
Type 2 diabetes and cardiovascular disease represent a serious threat to the health of the
population worldwide. Although overall adiposity and particularly visceral adiposity are …
population worldwide. Although overall adiposity and particularly visceral adiposity are …
The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study
BD Parker, LJ Schurgers, VM Brandenburg… - Annals of internal …, 2010 - acpjournals.org
Background: Fibroblast growth factor 23 (FGF23), uncarboxylated matrix Gla protein
(ucMGP), and fetuin-A are regulators of mineral metabolism and inhibitors of vascular …
(ucMGP), and fetuin-A are regulators of mineral metabolism and inhibitors of vascular …
Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK
Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease
(NAFLD). Recent studies identify mechanisms common to both diseases linked through an …
(NAFLD). Recent studies identify mechanisms common to both diseases linked through an …
Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease
Objective Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and is associated with cardiovascular risk. The aim of this study was to determine …
syndrome and is associated with cardiovascular risk. The aim of this study was to determine …