Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Healthy articular cartilage, covering the ends of bones in major joints such as hips and
knees, presents the most efficiently‐lubricated surface known in nature, with friction …

The increase in global lifespan has in turn increased the prevalence of osteoarthritis which
is now the most common type of arthritis. Cartilage tissue located on articular joints erodes …

Osteoarthritis is one of the leading causes of pain and disability in the aged population due
to articular cartilage damage. This warrants investigation of signaling mechanisms that could …

Tumor necrosis factor-(TNF) stimulated gene-6 (TSG-6) is an inflammation-associated
secreted protein that has been implicated as having important and diverse tissue protective …

Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …

Conspectus In the course of evolution, nature has achieved remarkably lubricated surfaces,
with healthy articular cartilage in the major (synovial) joints being the prime example, that …

Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …

Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …