[HTML][HTML] Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications

V Vrablova, N Kosutova, A Blsakova, A Bertokova… - Biotechnology …, 2023 - Elsevier
This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …

[HTML][HTML] Lectins as potential tools for cancer biomarker discovery from extracellular vesicles

MK Islam, M Khan, K Gidwani, KW Witwer… - Biomarker …, 2023 - Springer
Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and
therapeutic agents, in large part because molecular patterns on the EV surface betray the …

[HTML][HTML] Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

H Nie, P Saini, T Miyamoto, L Liao, RJ Zielinski… - Nature …, 2024 - nature.com
Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular
immunity. However, it's unclear whether homologous recombination (HR) status-dependent …

Therapeutic Applications of Stem Cell-Derived Exosomes

OAAY Abdulmalek, KH Husain, HKAA AlKhalifa… - International Journal of …, 2024 - mdpi.com
Exosomes are extracellular vesicles of endosomal origin, ranging from 30 to 150 nm in
diameter, that mediate intercellular transfer of various biomolecules, such as proteins, lipids …

[HTML][HTML] Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases

X Xie, S Kong, W Cao - Frontiers in Immunology, 2023 - frontiersin.org
Protein glycosylation is a widespread posttranslational modification that can impact the
function of proteins. Dysregulated protein glycosylation has been linked to several diseases …

Magnetic nanoagent assisted deciphering of heterogeneous glycans in extracellular vesicles of varied cellular origins

Y Yan, R Li, H Chen, Y Li, M Wu, Z Wang… - Biosensors and …, 2023 - Elsevier
Extracellular vesicles bear a rich glycome that presents versatile functions in diverse
biological processes. Leverage polydopamine modified magnetic particles to serve as …

Identification of animal species of origin in meat based on glycopeptide analysis by UPLC–QTOF-MS

J Tai, H Hu, X Cao, X Liang, Y Lu, H Zhang - Analytical and Bioanalytical …, 2023 - Springer
Adulteration of meat and meat products causes a concerning threat for consumers. It is
necessary to develop novel robust and sensitive methods which can authenticate the origin …

[HTML][HTML] Large-scale column-free purification of bovine F-ATP synthase

C Jiko, Y Morimoto, T Tsukihara, C Gerle - Journal of Biological Chemistry, 2024 - ASBMB
Mammalian F-ATP synthase is central to mitochondrial bioenergetics and is present in the
inner mitochondrial membrane in a dynamic oligomeric state of higher oligomers, tetramers …

Dielectrophoretic Capture of Cancer‐Derived Small‐Extracellular‐Vesicle‐Bound Janus Nanoparticles via Lectin–Glycan Interaction

Y Choi, K Akyildiz, J Seong, Y Lee… - Advanced …, 2024 - Wiley Online Library
Glycosylation is closely related to cellular metabolism and disease progression. In particular,
glycan levels in cancer cells and tissues increase during cancer progression. This …

[HTML][HTML] Cell Membrane Sialome: Sialic Acids as Therapeutic Targets and Regulators of Drug Resistance in Human Cancer Management

P Jastrząb, K Narejko, H Car, P Wielgat - Cancers, 2023 - mdpi.com
Simple Summary The aberrant sialylation of membrane glycocalyx plays a pivotal role in the
regulation of malignant cell behavior and correlates with a worse prognosis and shorter …