The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

The p53 protein is one of the most important tumor suppressors that are frequently
inactivated in cancer cells. This inactivation occurs either because the TP53 gene is mutated …

A unique series of pyrazolyl-chalcone derivatives was synthesized via the method of Claisen–
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …

We designed and prepared a novel series of urea derivatives with/without sulfonyl group in
their structures to investigate the impact of the sulfonyl group on the biological activity of the …

A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …

Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation
reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the …

A novel series of bis (furan‐based chalcone) derivatives linked to aliphatic linkers, with the
furan units at the A‐or B‐rings, were synthesized and evaluated as anticancer agents …

A new series of pyrazolyl–chalcone derivatives was prepared in moderate yields via Claisen–
Schmidt condensation reaction of 4-acetylpyrazole derivatives with the corresponding …

A novel series of six [1, 2, 4] triazolo [3, 4-a] isoquinolin-3-yl)-3-(1, 3-diphenyl-1 H-pyrazol-4-
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …

Chalcones are interesting anticancer drug candidates which have attracted much interest
due to their unique structure and their extensive biological activity. Various functional …