[HTML][HTML] What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines
D Széliová, DE Ruckerbauer, SN Galleguillos… - Metabolic …, 2020 - Elsevier
Background Cell line-specific, genome-scale metabolic models enable rigorous and
systematic in silico investigation of cellular metabolism. Such models have recently become …
systematic in silico investigation of cellular metabolism. Such models have recently become …
Omics and CRISPR in CHO bioproduction: a state-of-the-art review
S Sorourian, A Behzad Behbahani… - Biotechnology and …, 2024 - Springer
Chinese hamster ovary (CHO) cells have been routinely used as a factory for recombinant
proteins for several years, and their improvements have been the focus of consideration …
proteins for several years, and their improvements have been the focus of consideration …
[HTML][HTML] The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling
The accurate estimation of cell growth or the substrate consumption rate is crucial for the
understanding of the current state of a bioprocess. Rates unveil the actual cell status …
understanding of the current state of a bioprocess. Rates unveil the actual cell status …
[HTML][HTML] A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells
P Eisenhut, G Klanert, M Weinguny, L Baier… - Metabolic …, 2018 - Elsevier
Manipulation of multiple genes to engineer Chinese Hamster Ovary (CHO) cells for better
performance in production processes of biopharmaceuticals has recently become more and …
performance in production processes of biopharmaceuticals has recently become more and …
CHOmpact: a reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
I Jiménez del Val, S Kyriakopoulos, S Albrecht… - bioRxiv, 2021 - biorxiv.org
Metabolic modelling has emerged as a key tool for the characterisation of biopharmaceutical
cell culture processes. Metabolic models have also been instrumental in identifying genetic …
cell culture processes. Metabolic models have also been instrumental in identifying genetic …
Mathematical modelling of cell culture processes
V Chotteau, E Hagrot, L Zhang… - Cell Culture Engineering …, 2022 - Springer
The present chapter focusses on mechanistic models of mammalian cell bioprocesses used
for the production of biopharmaceuticals. Different types of models can be used to simulate …
for the production of biopharmaceuticals. Different types of models can be used to simulate …