Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Obesity predisposes individuals to the development of insulin resistance in skeletal muscle
and the liver, and researchers have recently proposed two mechanisms by which excess …

OBJECTIVE—To quantitate plasma ceramide subspecies concentrations in obese subjects
with type 2 diabetes and relate these plasma levels to the severity of insulin resistance …

The milk fat globule membrane (MFGM) has gained a lot of attention recently, due to the
growing interest in its nutritional and technological properties. The whole membrane as well …

Eukaryotic organisms as well as some prokaryotes and viruses contain sphingolipids, which
are defined by a common structural feature, ie, a “sphingoid base” backbone such as D …

The optimum approach to conquering cancer is prevention. Although the human diet
contains components which promote cancer, it also contains components with the potential …

Sphingomyelin is found in plasma membranes and related organelles (such as endocytic
vesicles and lysosomes) of all tissues, as well as in lipoproteins. Abnormalities in …

The identification of natural bioactive compounds aimed at promoting optimal gut health and
improving lipid metabolism is paramount in the prevention of chronic disease. In this review …

The α-Gal syndrome is a complex allergic disease characterized by the development of
specific IgE antibodies against the carbohydrate galactose-α-1, 3-galactose (α-Gal), an …

Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and
neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and …