Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

How western diet and lifestyle drive the pandemic of obesity and civilization diseases

W Kopp - Diabetes, metabolic syndrome and obesity: targets and …, 2019 - Taylor & Francis
Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

The impact of oxidative stress in human pathology: Focus on gastrointestinal disorders

R Vona, L Pallotta, M Cappelletti, C Severi… - Antioxidants, 2021 - mdpi.com
Accumulating evidence shows that oxidative stress plays an essential role in the
pathogenesis and progression of many diseases. The imbalance between the production of …

[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

Aging of the cells: Insight into cellular senescence and detection Methods

NSM Kamal, S Safuan, S Shamsuddin… - European journal of cell …, 2020 - Elsevier
Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …

Protective effects of natural polysaccharides on intestinal barrier injury: A review

J Huo, Z Wu, W Sun, Z Wang, J Wu… - Journal of agricultural …, 2022 - ACS Publications
Owing to their minimal side effects and effective protection from oxidative stress,
inflammation, and malignant growth, natural polysaccharides (NPs) are a potential adjuvant …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Glycine metabolism and its alterations in obesity and metabolic diseases

A Alves, A Bassot, AL Bulteau, L Pirola, B Morio - Nutrients, 2019 - mdpi.com
Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen
atom as a side-chain. In addition to being a building-block for proteins, glycine is also …

Biomarkers of oxidative stress in metabolic syndrome and associated diseases

R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …