The nanoparticle biomolecule corona: lessons learned–challenge accepted?

D Docter, D Westmeier, M Markiewicz… - Chemical Society …, 2015 - pubs.rsc.org
Besides the wide use of engineered nanomaterials (NMs) in technical products, their
applications are not only increasing in biotechnology and biomedicine, but also in the …

Artificial intelligence and machine learning empower advanced biomedical material design to toxicity prediction

AV Singh, D Rosenkranz, MHD Ansari… - Advanced Intelligent …, 2020 - Wiley Online Library
Materials at the nanoscale exhibit specific physicochemical interactions with their
environment. Therefore, evaluating their toxic potential is a primary requirement for …

Protein bio-corona: critical issue in immune nanotoxicology

M Neagu, Z Piperigkou, K Karamanou, AB Engin… - Archives of …, 2017 - Springer
With the expansion of the nanomedicine field, the knowledge focusing on the behavior of
nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex …

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

FM Kashkooli, M Soltani, M Souri, C Meaney… - Nano Today, 2021 - Elsevier
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

Liposome–protein corona in a physiological environment: challenges and opportunities for targeted delivery of nanomedicines

G Caracciolo - Nanomedicine: Nanotechnology, Biology and Medicine, 2015 - Elsevier
Active targeting that exploits the (over) expression of surface receptors in target cells by
ligand incorporation is a central concept in nanomedicine research. Despite unprecedented …

The effect of surface charge of functionalized Fe3O4 nanoparticles on protein adsorption and cell uptake

MP Calatayud, B Sanz, V Raffa, C Riggio, MR Ibarra… - Biomaterials, 2014 - Elsevier
Nanoparticles engineered for biomedical applications are meant to be in contact with protein-
rich physiological fluids. These proteins are usually adsorbed onto the nanoparticle's …

Mathematical modeling in cancer nanomedicine: a review

P Dogra, JD Butner, Y Chuang, S Caserta, S Goel… - Biomedical …, 2019 - Springer
Cancer continues to be among the leading healthcare problems worldwide, and efforts
continue not just to find better drugs, but also better drug delivery methods. The need for …

Materials, surfaces, and interfacial phenomena in nanoplastics toxicology research

LMA Martin, N Gan, E Wang, M Merrill, W Xu - Environmental Pollution, 2022 - Elsevier
In response to the growing worldwide plastic pollution problem, the field of nanoplastics
research is attempting to determine the risk of exposure to nanoparticles amidst their ever …

Adsorption and unfolding of a single protein triggers nanoparticle aggregation

S Dominguez-Medina, L Kisley, LJ Tauzin, A Hoggard… - ACS …, 2016 - ACS Publications
The response of living systems to nanoparticles is thought to depend on the protein corona,
which forms shortly after exposure to physiological fluids and which is linked to a wide array …

Engineered nanomaterial uptake and tissue distribution: from cell to organism

H Kettiger, A Schipanski, P Wick… - International journal of …, 2013 - Taylor & Francis
Improved understanding of interactions between nanoparticles and biological systems is
needed to develop safety standards and to design new generations of nanomaterials. This …