Mesenchymal stromal/stem cells (MSCs) perform their therapeutic effects through various
mechanisms, including their ability to differentiate, producing different growth factors …

Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from
one cell to another, can affect cellular and tissue homeostasis. Most of what we know about …

In multicellular organisms, interactions between cells and intercellular communications form
the very basis of the organism's survival, the functioning of its systems, the maintenance of …

The microenvironment plays a crucial role in stem cell differentiation, and a scaffold that
mimics native cartilaginous extracellular components can promote chondrogenesis. In this …

Mitochondria, the dynamic organelles responsible for energy production and cellular
metabolism, have the metabolic function of extracting energy from nutrients and synthesizing …

Mitochondria are metabolic and signalling hubs that integrate a plethora of interconnected
processes to maintain cell homeostasis. They are also dormant mediators of inflammation …

Despite various available treatments, highly prevalent osteoarthritis cannot be cured in
patients. In light of evidence showing mitochondria dysfunction during the disease …

Temporomandibular joint osteoarthritis (TMJOA) is considered to be a low-grade
inflammatory disease involving multiple joint tissues. The crosstalk between synovium and …

The prevalence of age-related degenerative joint diseases, particularly intervertebral disc
degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the …

Background Mitochondrial dysfunction induces chondrocyte senescence, thereby
precipitating articular cartilage (AC) degeneration in the pathogenesis of osteoarthritis (OA) …