Targeting PI3K-AKT/mTOR signaling in the prevention of autism
A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …
for mammalian enzyme-related receptors in transducing signals or biological processes …
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …
involved during embryonic development and later life stages. Further, it regulates cell …
Nrf2/HO-1 signaling activator acetyl-11-keto-beta Boswellic acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-induced experimental model of ALS
E Minj, S Upadhayay, S Mehan - Neurochemical research, 2021 - Springer
Methylmercury (MeHg) is a potent neurotoxin that causes neurotoxicity and neuronal cell
death. MeHg exposure also leads to oligodendrocyte destruction, glial cell overactivation …
death. MeHg exposure also leads to oligodendrocyte destruction, glial cell overactivation …
Guggulsterone mediated JAK/STAT and PPAR-gamma modulation prevents neurobehavioral and neurochemical abnormalities in propionic acid-induced …
Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …
challenges in verbal and non-verbal communication, poor socio-emotional health, and …
Nrf2/HO-1 signaling stimulation through acetyl-11-keto-beta-boswellic acid (AKBA) provides neuroprotection in ethidium bromide-induced experimental model of …
Multiple sclerosis (MS) is a severe immune-mediated neurological disease characterized by
neuroinflammation, demyelination, and axonal degeneration in the central nervous system …
neuroinflammation, demyelination, and axonal degeneration in the central nervous system …
Matrine mediated neuroprotective potential in experimental multiple sclerosis: evidence from CSF, blood markers, brain samples and in-silico investigations
Multiple sclerosis (MS) is a debilitating, inflammatory, and demyelinating disease of the
central nervous system influenced by environmental and genetic factors. Around 2.8 million …
central nervous system influenced by environmental and genetic factors. Around 2.8 million …
Acetyl-11-keto-beta boswellic acid (AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive …
Obsessive-Compulsive disorder (OCD) is a long-term and persistent mental illness
characterised by obsessive thoughts and compulsive behaviours. Numerous factors can …
characterised by obsessive thoughts and compulsive behaviours. Numerous factors can …
Activation of IGF-1/GLP-1 signalling via 4-hydroxyisoleucine prevents motor neuron impairments in experimental ALS-rats exposed to methylmercury-induced …
Amyotrophic lateral sclerosis (ALS) is a severe adult motor neuron disease that causes
progressive neuromuscular atrophy, muscle wasting, weakness, and depressive-like …
progressive neuromuscular atrophy, muscle wasting, weakness, and depressive-like …
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism …
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder marked by
social and communication deficits as well as repetitive behaviour. Several studies have …
social and communication deficits as well as repetitive behaviour. Several studies have …
Smo-Shh agonist Purmorphamine prevents neurobehavioral and neurochemical defects in 8-OH-DPAT-induced experimental model of obsessive-compulsive …
Obsessive-compulsive disorder is a mental disorder characterized by repetitive, unwanted
thoughts and behavior due to abnormal neuronal corticostriatal-thalamocortical pathway …
thoughts and behavior due to abnormal neuronal corticostriatal-thalamocortical pathway …