Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

Non-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from
the early stages of development until adulthood. Due to its capacity to convert chemical …

The role of myosin in the contraction of striated muscle cells is well known, but its importance
in nonmuscle cells is not yet clear. The function of myosin in Dictyostelium discoideum has …

Members of the myosin superfamily are actin-based molecular motors that are
indispensable for cellular homeostasis. The vast functional and structural diversity of …

A remarkable variety of extracellular signalling molecules effect signal transduction by
receptormediated increases in cytosolic Ca2 concentration. This Ca2 response is a central …

Regulation of cytoplasmic and smooth muscle myosin Page 1 Regulation of cytoplasmic and
smooth muscle myosin James R. Sellers National Institutes of Health, Bethesda, Maryland, USA …

Electron microscope studies have shown that the switched-off state of myosin II in muscle
involves intramolecular interaction between the two heads of myosin and between one head …

We have investigated the role of myosin in cytokinesis in Dictyostelium cells by examining
cells under both adhesive and nonadhesive conditions. On an adhesive surface, both wild …

Cells are frequently required to move in a local environment that physically restricts
locomotion, such as during extravasation or metastatic invasion. In order to model these …

We have identified a Dictyostelium discoideum gene encoding a serine/threonine kinase,
PAKa, a putative member of the Ste20/PAK family of p21-activated kinases, with a kinase …