The role of gene-environment interactions in social dysfunction: Focus on preclinical evidence from mouse studies
G Castellano, JB Da Silva, S Pietropaolo - Neuropharmacology, 2024 - Elsevier
Human and animal research has demonstrated that genetic and environmental factors can
strongly modulate behavioral function, including the expression of social behaviors and their …
strongly modulate behavioral function, including the expression of social behaviors and their …
Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies
S Wang, OO Ojewunmi, A Kamiza, M Ramsay… - Communications …, 2024 - nature.com
Meta-analysis of genome-wide association studies (GWAS) across diverse populations
offers power gains to identify loci associated with complex traits and diseases. Often …
offers power gains to identify loci associated with complex traits and diseases. Often …
Estimation of a genetic Gaussian network using GWAS summary data
ABSTRACT A genetic Gaussian network of multiple phenotypes, constructed through the
inverse matrix of the genetic correlation matrix, is informative for understanding the …
inverse matrix of the genetic correlation matrix, is informative for understanding the …
LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and …
Gene–environment (GE) interactions are essential in understanding human complex traits.
Identifying these interactions is necessary for deciphering the biological basis of such traits …
Identifying these interactions is necessary for deciphering the biological basis of such traits …
The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model
GB Chen - Behavior Genetics, 2024 - Springer
Haseman-Elston regression (HE-reg) has been known as a classic tool for detecting an
additive genetic variance component. However, in this study we find that HE-reg can capture …
additive genetic variance component. However, in this study we find that HE-reg can capture …
Investigating the Role of Neighborhood Socioeconomic Status and Germline Genetics on Prostate Cancer Risk
Background: Genetic factors play an important role in prostate cancer (PCa) development
with polygenic risk scores (PRS) predicting disease risk across genetic ancestries. However …
with polygenic risk scores (PRS) predicting disease risk across genetic ancestries. However …
The breadth and impact of the Global Lipids Genetics Consortium
The GLGC has significantly advanced the understanding of the genetic basis of lipid levels
and serves as the leading resource of GWAS summary statistics for these traits. Continued …
and serves as the leading resource of GWAS summary statistics for these traits. Continued …
Role of Endogenous and Exogenous Factors in Chronic Disease Development and Progression
DA Leone - 2024 - search.proquest.com
Genetic and molecular factors associated with chronic lung and kidney disease
susceptibility, leading causes of domestic and global mortality, remain largely unexplained …
susceptibility, leading causes of domestic and global mortality, remain largely unexplained …