The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlapping …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Calorie restriction extends life-span in a wide variety of organisms. Although it has been
suggested that calorie restriction may work by reducing the levels of reactive oxygen species …

Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar
over respiration. We now reveal an evolutionary conserved mechanism linking fermentation …

Yeast cells possess a remarkable capacity to adhere to abiotic surfaces, cells and tissues.
These adhesion properties are of medical and industrial relevance. Pathogenic yeasts such …

Cellular differentiation, mating, and filamentous growth are regulated in many fungi by
environmental and nutritional signals. For example, in response to nitrogen limitation …

The ability of pathogenic fungi to switch between a multicellular hyphal and unicellular yeast
growth form is a tightly regulated process known as dimorphic switching. Dimorphic …

Eukaryotic cells possess an exquisitely interwoven and fine-tuned series of signal
transduction mechanisms with which to sense and respond to the ubiquitous fermentable …

The cAMP–protein kinase A (PKA) pathway in the yeast Saccharomyces cerevisiae plays a
major role in the control of metabolism, stress resistance and proliferation, in particular in …