Non-alcoholic fatty liver disease–a global public health perspective

ZM Younossi - Journal of hepatology, 2019 - Elsevier
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence
of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of …

Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver

GH Goossens, JWE Jocken, EE Blaak - Nature Reviews Endocrinology, 2021 - nature.com
Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

[HTML][HTML] Obesity in adults: a clinical practice guideline

S Wharton, DCW Lau, M Vallis, AM Sharma, L Biertho… - Cmaj, 2020 - Can Med Assoc
This guideline update reflects substantial advances in the epidemiology, determinants,
pathophysiology, assessment, prevention and treatment of obesity, and shifts the focus of …

Age and sex are critical factors in ischemic stroke pathology

M Roy-O'Reilly, LD McCullough - Endocrinology, 2018 - academic.oup.com
Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of
function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional …

Pathophysiology of human visceral obesity: an update

A Tchernof, JP Després - Physiological reviews, 2013 - journals.physiology.org
Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Ovarian hormones and obesity

B Leeners, N Geary, PN Tobler… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND Obesity is caused by an imbalance between energy intake, ie eating and
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Sex differences in human adipose tissues–the biology of pear shape

K Karastergiou, SR Smith, AS Greenberg… - Biology of sex …, 2012 - Springer
Women have more body fat than men, but in contrast to the deleterious metabolic
consequences of the central obesity typical of men, the pear-shaped body fat distribution of …

Assessing adiposity: a scientific statement from the American Heart Association

MA Cornier, JP Després, N Davis, DA Grossniklaus… - Circulation, 2011 - Am Heart Assoc
The prevalence of obesity in the United States and the world has risen to
epidemic/pandemic proportions. This increase has occurred despite great efforts by …

Sex-specific differences in lipid and glucose metabolism

O Varlamov, CL Bethea, CT Roberts Jr - Frontiers in endocrinology, 2015 - frontiersin.org
Energy metabolism in humans is tuned to distinct sex-specific functions that potentially
reflect the unique requirements in females for gestation and lactation, whereas male …