Thyroid carcinoma‐featured telomerase activation and telomere maintenance: Biology and translational/clinical significance
X Yuan, H Yuan, N Zhang, T Liu… - Clinical and Translational …, 2022 - Wiley Online Library
Background Telomerase is a ribonucleoprotein complex consisting of a catalytic component
telomerase reverse transcriptase (TERT), internal RNA template and other co‐factors, and …
telomerase reverse transcriptase (TERT), internal RNA template and other co‐factors, and …
TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance
T Liu, S Li, C Xia, D Xu - Frontiers in Immunology, 2023 - frontiersin.org
Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG
sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated …
sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated …
The cuproptosis-associated 13 gene signature as a robust predictor for outcome and response to immune-and targeted-therapies in clear cell renal cell carcinoma
H Yuan, X Qin, J Wang, Q Yang, Y Fan… - Frontiers in …, 2022 - frontiersin.org
Cuproptosis, the newly identified form of regulatory cell death (RCD), results from
mitochondrial proteotoxic stress mediated by copper and FDX1. Little is known about …
mitochondrial proteotoxic stress mediated by copper and FDX1. Little is known about …
ETS transcription factors: Multifaceted players from cancer progression to tumor immunity
Y Wang, Z Huang, M Sun, W Huang, L Xia - Biochimica et Biophysica Acta …, 2023 - Elsevier
The E26 transformation specific (ETS) family comprises 28 transcription factors, the majority
of which are involved in tumor initiation and development. Serving as a group of functionally …
of which are involved in tumor initiation and development. Serving as a group of functionally …
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma
H Yuan, X Qin, Q Yang, L Liu, Z Fang, Y Fan… - Biology of Sex …, 2023 - Springer
Background Clear cell renal cell carcinoma (ccRCC) displays sex-biased incidence,
outcomes, molecular alterations and treatment efficacy; however, clinical managements are …
outcomes, molecular alterations and treatment efficacy; however, clinical managements are …
A regulatory network controlling ovarian granulosa cell death
L Yang, X Du, S Wang, C Lin, Q Li, Q Li - Cell Death Discovery, 2023 - nature.com
Follicular atresia triggered by granulosa cell (GC) apoptosis severely reduces female fertility
and accelerates reproductive aging. GC apoptosis is a complex process regulated by …
and accelerates reproductive aging. GC apoptosis is a complex process regulated by …
Cuproptosis and its application in different cancers: an overview
L Xu, K Liu, F Wang, Y Su - Molecular and Cellular Biochemistry, 2023 - Springer
Heavy metal ions are essential micronutrients for human health. They are also
indispensable to maintaining health and regular operation of organs. Increasing or …
indispensable to maintaining health and regular operation of organs. Increasing or …
Targeting tumor endothelial cells with methyltransferase inhibitors: mechanisms of action and the potential of combination therapy
S Zhou, H Ou, Y Wu, D Qi, X Pei, X Yu, X Hu… - Pharmacology & …, 2023 - Elsevier
Tumor endothelial cells (TECs) reside in the inner lining of blood vessels and represent a
promising target for targeted cancer therapy. DNA methylation is a chemical process that …
promising target for targeted cancer therapy. DNA methylation is a chemical process that …
[HTML][HTML] Abnormal changes in metabolites caused by m6A methylation modification: The leading factors that induce the formation of immunosuppressive tumor …
L Zhao, J Guo, S Xu, M Duan, B Liu, H Zhao… - Journal of Advanced …, 2024 - Elsevier
Abstract Background N6-methyladenosine (m 6 A) RNA methylation modifications have
been widely implicated in the metabolic reprogramming of various cell types within the tumor …
been widely implicated in the metabolic reprogramming of various cell types within the tumor …
Comprehensive analyses of the cancer-associated fibroblast subtypes and their score system for prediction of outcomes and immunosuppressive microenvironment in …
Z Gao, N Zhang, B An, D Li, Z Fang, D Xu - Cancer Cell International, 2024 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) drive cancer progression and
treatment failure on one hand, while their tumor-restraining functions are also observed on …
treatment failure on one hand, while their tumor-restraining functions are also observed on …