ROS homeostasis and metabolism: a dangerous liason in cancer cells
E Panieri, MM Santoro - Cell death & disease, 2016 - nature.com
Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …
TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target
EH Choi, SJ Park - Experimental & Molecular Medicine, 2023 - nature.com
Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …
Thioredoxin reductase inhibition for cancer therapy
R Gencheva, ESJ Arnér - Annual Review of Pharmacology and …, 2022 - annualreviews.org
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system
Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
Reactive oxygen species in normal and tumor stem cells
Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …
[HTML][HTML] Glutaredoxin: Discovery, redox defense and much more
Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …
[HTML][HTML] The roles of peroxiredoxin and thioredoxin in hydrogen peroxide sensing and in signal transduction
A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
K Frudd, T Burgoyne, JR Burgoyne - Nature communications, 2018 - nature.com
Macroautophagy (autophagy) is a crucial cellular stress response for degrading defective
macromolecules and organelles, as well as providing bioenergetic intermediates during …
macromolecules and organelles, as well as providing bioenergetic intermediates during …
The conundrum of hydrogen peroxide signaling and the emerging role of peroxiredoxins as redox relay hubs
S Stöcker, K Van Laer, A Mijuskovic… - Antioxidants & redox …, 2018 - liebertpub.com
Abstract Significance: Hydrogen peroxide (H2O2) is known to act as a messenger in signal
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …
Thioredoxin reductase as a pharmacological target
Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …