[HTML][HTML] Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
[HTML][HTML] Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis
M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children
A Wollenberg, S Christen‐Zäch, A Taieb… - Journal of the …, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis
is made using evaluated clinical criteria. Disease activity and burden are best measured …
is made using evaluated clinical criteria. Disease activity and burden are best measured …
[HTML][HTML] IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation
W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …
system. They profoundly participate in immune responses during infection and inflammation …
[HTML][HTML] Pathophysiology of atopic dermatitis: Clinical implications
J Kim, BE Kim, DYM Leung - Allergy and asthma proceedings, 2019 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic
predisposition, epidermal barrier disruption, and dysregulation of the immune system are …
predisposition, epidermal barrier disruption, and dysregulation of the immune system are …
Update on the pathogenesis and therapy of atopic dermatitis
H Li, Z Zhang, H Zhang, Y Guo, Z Yao - Clinical reviews in allergy & …, 2021 - Springer
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent
eczematous lesions and intense itch. Although it most often starts in infancy and affects …
eczematous lesions and intense itch. Although it most often starts in infancy and affects …
[HTML][HTML] Impact of genetic polymorphisms on human immune cell gene expression
While many genetic variants have been associated with risk for human diseases, how these
variants affect gene expression in various cell types remains largely unknown. To address …
variants affect gene expression in various cell types remains largely unknown. To address …
[HTML][HTML] Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis
E Guttman-Yassky, R Bissonnette, B Ungar… - Journal of Allergy and …, 2019 - Elsevier
Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …
[HTML][HTML] The role of IL-22 in intestinal health and disease
The role of IL-22 in intestinal health and disease | Journal of Experimental Medicine |
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Atopic dermatitis endotypes and implications for targeted therapeutics
T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …