Endothelial colony forming cells (ECFCs) represent the most suitable cellular substrate to
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …

Intracellular Ca 2+ ions that are thought to be one of the most important second messengers
for cellular signaling, have a substantial diversity of roles in regulating a plethora of …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second
messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal …

Mechanical stretch is one type of common physiological activities such as during heart
beating, lung breathing, blood flow through the vessels, and physical exercise. The …

Excess consumption of carbohydrates, fat and calories leads to non‐alcoholic fatty liver
disease (NAFLD) and hepatic insulin resistance; these are major factors in the pathogenesis …

The role of Ca 2+ release-activated Ca 2+(CRAC) channels mediated by ORAI isoforms in
calcium signalling has been extensively investigated. It has been shown that the presence …

Red blood cells (RBCs) exhibit an interesting response to hydrodynamic flow, releasing
adenosine triphosphate (ATP). Subsequently, these liberated ATP molecules initiate a …

Theoretical studies on calcium oscillations within the cytosolic Ca ^2+, and mitochondria Ca
^2+ _mit have been conducted using a mathematical model-based approach. The model …

Various types of cells demonstrate ubiquitous rhythmicity registered as simple and complex
Ca2+-oscillations, spikes, waves, and triggering phenomena mediated by G-protein and …

The integrative study that included experimentation and mathematical modeling was carried
out to analyze dynamic aspects of transient Ca 2+ signaling induced by brief pulses of …