The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …

Hyaluronan is a widely distributed extracellular component of connective tissue with several
mechanical and cell biological functions. The serum level of hyaluronan is elevated in …

Endo180, a member of the mannose receptor family, is constitutively recycled between
clathrin-coated pits on the cell surface and intracellular endosomes. Its large extracellular …

The liver is constantly exposed to dietary antigens, viruses, and bacterial products with
inflammatory potential. For decades cellular uptake of virus has been studied in connection …

The purpose of this study was to identify the receptor responsible for endocytosis of
denatured collagen from blood. The major site of clearance of this material (at least 0.5 …

BACKGROUND/AIMS: Bacterial DNA and synthetic oligonucleotides containing
unmethylated motifs have become the focus of many studies due to their ability to activate …

Liver sinusoidal endothelial cells (LSECs) are largely responsible for the removal of
circulating lysosomal enzymes (LE) via mannose receptor (MR)‐mediated endocytosis. We …

Liver sinusoidal endothelial cells (LSECs) are specialized scavenger cells that mediate high-
capacity clearance of soluble waste macromolecules and colloid material, including blood …