Esophageal cancer: emerging therapeutics

JE Rogers, M Sewastjanow-Silva… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Esophageal cancer (EC) is a worldwide healthcare concern and represents an
aggressive malignancy. Squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) are …

The anti-PD-1/PD-L1 immunotherapy for gastric esophageal cancer: a systematic review and meta-analysis and literature review

K Chen, X Wang, L Yang, Z Chen - Cancer Control, 2021 - journals.sagepub.com
Background: Treatment options for advanced gastric esophageal cancer are quite limited.
Chemotherapy is unavoidable at certain stages, and research on targeted therapies has …

LncRNA MAGI2-AS3 Overexpression Sensitizes Esophageal Cancer Cells to Irradiation Through Down-Regulation of HOXB7 via EZH2

W Cheng, X Shi, M Lin, Q Yao, J Ma… - Frontiers in Cell and …, 2020 - frontiersin.org
Background Accumulating evidence has suggested that aberrant expression of long non-
coding RNAs (lncRNAs) may contribute to cancer progression in association with …

Mechanisms of pharmaceutical therapy and drug resistance in esophageal cancer

C Mao, X Zeng, C Zhang, Y Yang, X Xiao… - Frontiers in Cell and …, 2021 - frontiersin.org
Pharmaceutical therapies are essential for esophageal cancer (EC). For the advanced EC,
the neoadjuvant therapy regimen, including chemotherapy plus radiotherapy and/or …

[HTML][HTML] Platelet-to-lymphocyte ratio is an independent predictor of chemoradiotherapy-related esophageal fistula in esophageal cancer patients

D Han, J Zhang, J Zhao, T Lei, X Chen… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and
monocyte-to-lymphocyte ratio (MLR) are all markers of systemic inflammation response. The …

Esophageal microenvironment: from precursor microenvironment to premetastatic niche

P Han, P Cao, S Hu, K Kong, Y Deng… - Cancer Management …, 2020 - Taylor & Francis
Esophageal cancer (EC) is the sixth most deadly cancer, and its incidence is still increasing
year by year. Although the researches on the molecular mechanisms of EC have been …

Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling

M Komatsu, K Nakamura, T Takeda, F Chiwaki… - Oncogene, 2022 - nature.com
Oncogenic signalling confers tumour-progression advantages; thus, its pharmacological
blockade is the best strategy for cancer chemotherapy. However, drug resistance and …

Serine/threonine‐protein kinase D2‐mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression

YQ Liu, YW Xu, ZT Zheng, D Li, CQ Hong… - The Journal of …, 2024 - Wiley Online Library
Abstract Desmoglein‐2 (DSG2) is a transmembrane glycoprotein belonging to the
desmosomal cadherin family, which mediates cell–cell junctions; regulates cell proliferation …

Extracellular vesicle-mediated communication between CD8+ cytotoxic T cells and tumor cells

Z Huang, X Liu, Q Guo, Y Zhou, L Shi, Q Cai… - Frontiers in …, 2024 - frontiersin.org
Tumors pose a significant global public health challenge, resulting in numerous fatalities
annually. CD8+ T cells play a crucial role in combating tumors; however, their effectiveness …

RETRACTED ARTICLE: Let-7c-5p Inhibits Cell Proliferation and Migration and Promotes Apoptosis via the CTHRC1/AKT/ERK Pathway in Esophageal Squamous …

Y Zheng, M Luo, M Lü, T Zhou, F Liu, X Guo… - OncoTargets and …, 2020 - Taylor & Francis
Zheng Y, Luo M, Lü M, et al. Onco Targets Ther. 2020; 13: 11193–11209. At the author's
request, we, the Editors and Publisher of OncoTargets and Therapy, have retracted the …