Background Association studies of germline DNA repair single nucleotide polymorphisms
(SNPs) and glioma risk have yielded inconclusive results. We therefore performed a …

Background: Most of the heritable risk of glioma is presently unaccounted for by mutations in
known genes. In addition to rare inactivating germline mutations in TP53 causing glioma in …

The p53 gene is pivotal for oncogenesis in a combination of mutations in oncogenes and
antioncogenes. The ubiquitous loss of the p53 pathway in human cancers has generated …

Breast cancer is the most common oncological disease in women worldwide. Genetic
predisposition to breast cancer can be associated with single‐nucleotide polymorphisms …

The allelic variant MDM2-SNP309 (T> G) has been suggested to influence cancer
development, but the clinical correlation between the risk allele and breast cancer remains …

TP53 codon 72 polymorphism has been reported to affect regulatory networks central to
glioma development. Although a number of published studies noted the association …

The MDM2 gene is amplified and/or overexpressed in about 10% of glioblastomas and
constitutes one of a number of ways the p53 pathway is disrupted in these tumours. MDM2 …

The potentially functional polymorphism Arg72Pro in p53 gene has been implicated in
glioma risk, but published studies have mixed findings. The aim of current investigation was …

P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome
17p13. Many case–control studies have investigated the association between p53 codon 72 …

Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-
nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results …