Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …

Multiple myeloma (MM) is a malignancy that is often driven by MYC and that is sustained by
IRF4, which are upregulated by super-enhancers. IKZF1 and IKZF3 bind to super-enhancers …

SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …

In response to T-cell-dependent antigens, antigen-experienced B cells migrate to the center
of the B-cell follicle to seed the germinal center (GC) response after cognate interactions …

Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger
harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to …

The long-lasting humoral immunity induced by viral infections or vaccinations depends on
memory B cells with greatly increased affinity to viral antigens, which are evolved from …

Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D
mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas …

Limited infiltration and activity of natural killer (NK) and T cells within the tumor
microenvironment (TME) correlate with poor immunotherapy responses. Here, we examined …

Graph and image are two common representations of Hi-C cis-contact maps. Existing
computational tools have only adopted Hi-C data modeled as unitary data structures but …