The cellular response to complex DNA damage induced by ionising radiation

B Wilkinson, MA Hill, JL Parsons - International Journal of Molecular …, 2023 - mdpi.com
Radiotherapy (ionising radiation; IR) is utilised in the treatment of~ 50% of all human
cancers, and where the therapeutic effect is largely achieved through DNA damage …

Simulation of DNA damage using Geant4‐DNA: an overview of the “molecularDNA” example application

KP Chatzipapas, NH Tran, M Dordevic… - Precision Radiation …, 2023 - Wiley Online Library
Purpose The scientific community shows great interest in the study of DNA damage
induction, DNA damage repair, and the biological effects on cells and cellular systems after …

Electronic excitation response of DNA to high-energy proton radiation in water

C Shepard, DC Yost, Y Kanai - Physical Review Letters, 2023 - APS
The lack of molecular-level understanding for the electronic excitation response of DNA to
charged particle radiation, such as high-energy protons, remains a fundamental scientific …

Enhanced astaxanthin production of Haematococcus pluvialis strains induced salt and high light resistance with gamma irradiation

HE Yang, BS Yu, SJ Sim - Bioresource technology, 2023 - Elsevier
This study was conducted to increase the productivity of biomass that contains high
astaxanthin content by developing a mutant Haematococcus pluvialis strain with strong …

DNA Protection against Damages Induced by Low-Energy Electrons: Absolute Cross Sections for Arginine–DNA Complexes

X Wang, H Liao, W Liu, Y Shao, Y Zheng… - The Journal of …, 2023 - ACS Publications
Histone proteins protect cellular DNA from radiation damage. We find that arginine, a major
component of histone proteins, protects DNA from lesions induced by low-energy secondary …

Radical production with pulsed beams: understanding the transition to FLASH

A Espinosa-Rodriguez, D Sanchez-Parcerisa… - International Journal of …, 2022 - mdpi.com
Ultra-high dose rate (UHDR) irradiation regimes have the potential to spare normal tissue
while keeping equivalent tumoricidal capacity than conventional dose rate radiotherapy …

[HTML][HTML] Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA

D Sakata, R Hirayama, WG Shin, M Belli… - Physica Medica, 2023 - Elsevier
Abstract Purpose: Track structure Monte Carlo (MC) codes have achieved successful
outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim …

A review of recent advances in the modeling of nanoparticle radiosensitization with the Geant4-DNA toolkit

A Taheri, MU Khandaker, F Moradi… - Radiation Physics and …, 2023 - Elsevier
Metallic nanoparticles are promising agents for increasing the effectiveness of radiation
therapy by making cells more sensitive to radiation. High atomic number nanoparticles …

DNA damage clustering after ionizing radiation and consequences in the processing of chromatin breaks

V Mladenova, E Mladenov, M Stuschke, G Iliakis - Molecules, 2022 - mdpi.com
Charged-particle radiotherapy (CPRT) utilizing low and high linear energy transfer (low-
/high-LET) ionizing radiation (IR) is a promising cancer treatment modality having unique …

ICRU Report 98, Stochastic Nature of Radiation Interactions: Microdosimetry

LA Braby, V Conte, M Dingfelder… - Journal of the …, 2023 - journals.sagepub.com
ICRU Report 98, Stochastic Nature of Radiation Interactions: Microdosimetry - LA Braby, V.
Conte, M. Dingfelder, DT Goodhead, LS Pinsky, AB Rosenfeld, T. Sato, AJ Waker, S. Guatelli …