[HTML][HTML] The role of metallothionein in oxidative stress
Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …
be part of the molecule. They cause the molecule to become highly reactive. The free …
Metallothionein: an intracellular protein to protect against cadmium toxicity
CD Klaassen, J Liu, S Choudhuri - Annual review of …, 1999 - annualreviews.org
▪ Abstract Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …
Regulation of gene expression by reactive oxygen
TP Dalton, HG Shertzer, A Puga - Annual review of …, 1999 - annualreviews.org
▪ Abstract Reactive oxygen intermediates are produced in all aerobic organisms during
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …
Thiol-based antioxidants
SM Deneke - Current topics in cellular regulation, 2001 - Elsevier
Publisher Summary The thiol redox status of intracellular and extracellular compartments is
critical in the determination of protein structure, regulation of enzyme activity, and control of …
critical in the determination of protein structure, regulation of enzyme activity, and control of …
Cytosolic NADP+-dependent isocitrate dehydrogenase status modulates oxidative damage to cells
NADPH is an important cofactor in many biosynthesis pathways and the regeneration of
reduced glutathione, critically important in cellular defense against oxidative damage. It is …
reduced glutathione, critically important in cellular defense against oxidative damage. It is …
Induction, regulation, degradation, and biological significance of mammalian metallothioneins
AT Miles, GM Hawksworth, JH Beattie… - Critical reviews in …, 2000 - Taylor & Francis
MTs are small cysteine-rich metal-binding proteins found in many species and, although
there are differences between them, it is of note that they have a great deal of sequence and …
there are differences between them, it is of note that they have a great deal of sequence and …
The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease
B Mirza, H Hadberg, P Thomsen, T Moos - Neuroscience, 1999 - Elsevier
Virtually any neurological disorder leads to activation of resident microglia and invasion of
blood-borne macrophages, which are accompanied by an increase in number and change …
blood-borne macrophages, which are accompanied by an increase in number and change …
Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects
A Formigari, P Irato, A Santon - … and Physiology Part C: Toxicology & …, 2007 - Elsevier
Copper, zinc and iron are essential metals for different physiological functions, even though
their excess can lead to biological damage. This review provides a background of toxicity …
their excess can lead to biological damage. This review provides a background of toxicity …
The antioxidant function of metallothionein in the heart
YJ Kang - Proceedings of the Society for Experimental Biology …, 1999 - Wiley Online Library
The antioxidant function of metallothionein (MT) was first suggested in the early 1980s.
Studies in vitro have revealed that MT reacts directly with reactive oxygen species, including …
Studies in vitro have revealed that MT reacts directly with reactive oxygen species, including …
Free radical scavenging actions of metallothionein isoforms I and II
MVR Kumari, M Hiramatsu, M Ebadi - Free radical research, 1998 - Taylor & Francis
By employing electron spin resonance spectroscopy, we examined the free radicals
scavenging effects of hepatic metallothionein (MT) isoforms I and II (MTs-I and II) on four …
scavenging effects of hepatic metallothionein (MT) isoforms I and II (MTs-I and II) on four …