Dietary regulation in health and disease

Q Wu, ZJ Gao, X Yu, P Wang - Signal Transduction and Targeted …, 2022 - nature.com
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

[HTML][HTML] Promoting health and longevity through diet: from model organisms to humans

L Fontana, L Partridge - Cell, 2015 - cell.com
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

[HTML][HTML] Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

ME Levine, JA Suarez, S Brandhorst… - Cell metabolism, 2014 - cell.com
Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …

Decreased consumption of branched-chain amino acids improves metabolic health

L Fontana, NE Cummings, SIA Apelo, JC Neuman… - Cell reports, 2016 - cell.com
Summary Protein-restricted (PR), high-carbohydrate diets improve metabolic health in
rodents, yet the precise dietary components that are responsible for these effects have not …

Interventions to slow aging in humans: are we ready?

VD Longo, A Antebi, A Bartke, N Barzilai… - Aging cell, 2015 - Wiley Online Library
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

Influence of the Mediterranean diet on healthy aging

MC Andreo-López, V Contreras-Bolívar… - International Journal of …, 2023 - mdpi.com
The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …

Emerging role of exosomes as biomarkers in cancer treatment and diagnosis

NA Hanjani, N Esmaelizad, S Zanganeh… - Critical reviews in …, 2022 - Elsevier
Cancer is a leading cause of death worldwide and cancer incidence and mortality are
rapidly growing. These massive amounts of cancer patients require rapid diagnosis and …

Mediterranean diet and the hallmarks of ageing

OM Shannon, AW Ashor, F Scialo, G Saretzki… - European Journal of …, 2021 - nature.com
Ageing is a multifactorial process associated with reduced function and increased risk of
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …

[HTML][HTML] Association of plant-based diet index with prostate cancer risk

S Loeb, BC Fu, SR Bauer, CH Pernar, JM Chan… - The American journal of …, 2022 - Elsevier
Background Plant-based diets are associated with multiple health benefits and a favorable
environmental impact. For prostate cancer, previous studies suggest a beneficial role of …

Role of branched-chain amino acid metabolism in type 2 diabetes, obesity, cardiovascular disease and non-alcoholic fatty liver disease

P Cuomo, R Capparelli, A Iannelli… - International journal of …, 2022 - mdpi.com
Branched-chain amino acids (BCAAs) include leucine, isoleucine, and valine. Mammalians
cannot synthesize these amino acids de novo and must acquire them through their diet …