The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

Inflammatory bowel disease (IBD), as a global disease, has attracted much research
interest. Constant research has led to a better understanding of the disease condition and …

Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

Human epithelial organoids—3D spheroids derived from adult tissue stem cells—enable
investigation of epithelial physiology and disease and host interactions with …

Introduction: The gastrointestinal mucosa constitutes a critical barrier where millions of
microbes and environmental antigens come in close contact with the host immune system …

Alterations of the mycobiota composition associated with Crohn's disease (CD) are
challenging to link to defining elements of pathophysiology, such as poor injury repair. Using …

Here we describe a method for fabricating a primary human Small Intestine-on-a-Chip
(Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal …

Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …

Human enteroids—epithelial spheroids derived from primary gastrointestinal tissue—are a
promising model to study pathogen-epithelial interactions. However, accessing the apical …