Early observations of centrosomes, made a century ago, revealed a tiny dark structure
surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are …

CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate
the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of …

In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and
instead initiate DNA repair. Here, we show that, in response to genotoxic stress in G2, the …

The nucleolus is the most obvious and clearly differentiated nuclear subcompartment. It is
where ribosome biogenesis takes place and has been the subject of research over many …

The Cdc14 dual-specificity phosphatases regulate key events in the eukaryotic cell cycle.
However, little is known about the function of mammalian CDC14B family members. Here …

The nucleolus, although an integral part of all eukaryotic nuclei, plays by its own rules in
many respects. Cytologically, it is the most prominent subnuclear domain; functionally, it is …

We have characterized the CDC14 gene, which encodes a dual-specificity protein
phosphatase in Candida albicans, and demonstrated that its deletion results in defects in …

In eukaryotes, exit from mitosis occurs through the inactivation of the Cdk1-cyclin B kinase
complex and the reversal of its phosphorylation events. These late mitotic events are tightly …

CTCF is a ubiquitous epigenetic regulator that has been proposed as a master keeper of
chromatin organisation. CTCF-like, or BORIS, is thought to antagonise CTCF and has been …

Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are
universally required for mitotic exit. In budding yeast (Saccharomyces cerevisiae), Cdc14 is …