Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a
highly unusual and characteristic diderm cell envelope that protects them against harmful …

The rise of antibiotic resistance necessitates the search for new platforms for drug
development. Prodrugs are common tools for overcoming drawbacks typically associated …

Bacterial secretion systems were initially studied in the Gram‐negative bacterium
Escherichia coli K‐12. When researchers started to explore protein secretion in different …

We have investigated the role of Rv3097c-encoded lipase (LipY) on the virulence of
Mycobacterium tuberculosis. It has been shown that the overexpression of LipY in strain …

Lipids and lipid-metabolizing esterases/lipases are highly important for the mycobacterial
life cycle and, possibly, for mycobacterial virulence. In this study, we expressed 10 members …

The mycobacterial Rv3097c-encoded lipase LipY is considered as a true lipase involved in
the hydrolysis of triacylglycerol stored in lipid inclusion bodies for the survival of dormant …

Mycobacterium leprae must adopt a metabolic strategy and undergo various metabolic
alterations upon infection to survive inside the human body for years in a dormant state. A …

Lipid inclusions play an important role in several pathological processes. Intracellular
bacterial pathogens, such as members of the Mycobacterium and Chlamydia species are …

Lipases catalyze the hydrolysis of triglycerides (TAG). Open reading frames (ORF) predicted
to encode enzymes involved in fatty acids breakdown are abundant in Mycobacterium …

Abstract Mycobacterium bovis Bacillus Calmette–Guérin (BCG), an attenuated vaccine
derived from M. bovis, is the only licensed vaccine against tuberculosis (TB). Despite its …