Objectives To summarize the evidence on the prevalence and preventability of drug‐related
hospital readmissions. Design A systematic review was performed of studies that examined …

The dramatic demographic changes that are occurring in the third millennium are modifying
the mission of generalist professionals such as primary care physicians and internists …

Background Several measures of medication exposure are associated with adverse
outcomes in older people. Exposure to and the clinical outcomes of these measures in …

The positive benefit–risk ratio of most drugs is decreasing in correlation to very old age, the
extent of comorbidity, dementia, frailty and limited life expectancy (VOCODFLEX). First, we …

Objectives We aimed to establish an explicit list of potentially clinically significant drug-drug
interactions (DDIs) in people aged≥ 65 years. Design A preliminary list of potentially …

As a consequence of population aging, we have witnessed in internal medicine hospital
wards a progressive shift from a population of in-patients relatively young and mainly …

Background Adverse drug events due to drug-drug interactions (DDIs) represent a
considerable public health burden, also in Slovenia. A better understanding of the most …

Background Polypharmacy is very common in elderly patients and is associated with
detrimental outcomes. Objective Our objective was to evaluate the associations between a …

Background The elderly are considered as special population, as they differ from younger
adults in terms of comorbidity, polypharmacy, pharmacokinetics, vulnerability to drug–drug …

What is known and objective Inappropriate prescribing is highly prevalent for older people
and has become a global healthcare concern because of its association with negative …