The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Epigallocatechin 3-gallate: From green tea to cancer therapeutics

M Alam, S Ali, GM Ashraf, AL Bilgrami, DK Yadav… - Food chemistry, 2022 - Elsevier
Abstract Epigallocatechin 3-gallate (EGCG) possesses various biological functions,
including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic …

Therapeutic implications of caffeic acid in cancer and neurological diseases

M Alam, S Ahmed, AM Elasbali, M Adnan… - Frontiers in …, 2022 - frontiersin.org
Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA
and its derivatives have been used for many centuries due to their natural healing and …

A retrospective-prospective review of Suzuki–Miyaura reaction: From cross-coupling reaction to pharmaceutical industry applications

M Farhang, AR Akbarzadeh, M Rabbani, AM Ghadiri - Polyhedron, 2022 - Elsevier
Carbon-carbon coupling is the most important reaction in chemical, academia, and industrial
scales. The Suzuki-Miyaura coupling is a cross-coupling reaction in which the coupling …

Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

S Ali, M Alam, F Khatoon, U Fatima, AM Elasbali… - Biomedicine & …, 2022 - Elsevier
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …

Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer

M Alam, S Alam, A Shamsi, M Adnan… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …

[HTML][HTML] Investigating regulated signaling pathways in therapeutic targeting of non-small cell lung carcinoma

M Alam, GM Hasan, SM Eldin, M Adnan… - Biomedicine & …, 2023 - Elsevier
Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The
signaling cascades are stimulated via genetic modifications in upstream signaling …

Metabolic health, mitochondrial fitness, physical activity, and cancer

VJ Clemente-Suárez, A Martín-Rodríguez… - Cancers, 2023 - mdpi.com
Simple Summary Recent research suggests a strong link between the functioning of
mitochondria and the development of cancer. Healthy mitochondria play a vital role in …

Therapeutic targeting of regulated signaling pathways of non-small cell lung carcinoma

GM Hasan, MI Hassan, SS Sohal, A Shamsi… - ACS omega, 2023 - ACS Publications
Non-small cell lung carcinoma (NSCLC) is the most common cancer globally.
Phytochemicals and small molecule inhibitors significantly prevent varying types of cancers …

Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies

N Yasser, FM Sroor, HM El-Shorbagy, SM Eissa… - RSC …, 2024 - pubs.rsc.org
A unique series of pyrazolyl-chalcone derivatives was synthesized via the method of Claisen–
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …