Klebsiella pneumoniae infection biology: living to counteract host defences

JA Bengoechea, J Sa Pessoa - FEMS microbiology reviews, 2019 - academic.oup.com
Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Klebsiella pneumoniae: going on the offense with a strong defense

MK Paczosa, J Mecsas - Microbiology and molecular biology …, 2016 - Am Soc Microbiol
Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Molecular Pathogenesis of Klebsiella Pneumoniae

B Li, Y Zhao, C Liu, Z Chen, D Zhou - Future microbiology, 2014 - Taylor & Francis
Typical Klebsiella pneumoniae is an opportunistic pathogen, which mostly affects those with
weakened immune systems and tends to cause nosocomial infections. A subset of …

The making of hypervirulent Klebsiella pneumoniae

P Dai, D Hu - Journal of Clinical Laboratory Analysis, 2022 - Wiley Online Library
Klebsiella pneumoniae is a notorious bacterium in clinical practice. Virulence, carbapenem‐
resistance and their convergence among K. pneumoniae are extensively discussed in this …

Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella

JL Insua, E Llobet, D Moranta… - Infection and …, 2013 - Am Soc Microbiol
The implementation of infection models that approximate human disease is essential for
understanding pathogenesis at the molecular level and for testing new therapies before they …

Klebsiella pneumoniae: Prevalence, Reservoirs, Antimicrobial Resistance, Pathogenicity, and Infection: A Hitherto Unrecognized Zoonotic Bacterium

Y Hu, J Anes, S Devineau, S Fanning - Foodborne pathogens and …, 2021 - liebertpub.com
Klebsiella pneumoniae is considered an opportunistic pathogen, constituting an ongoing
health concern for immunocompromised patients, the elderly, and neonates. Reports on the …

Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae

A Gomez-Simmonds… - The Journal of infectious …, 2017 - academic.oup.com
Klebsiella pneumoniae poses a major challenge to healthcare worldwide as an important
cause of multidrug-resistant infections. Nosocomial clones, including epidemic sequence …

Deciphering tissue-induced Klebsiella pneumoniae lipid A structure

E Llobet, V Martínez-Moliner… - Proceedings of the …, 2015 - National Acad Sciences
The outcome of an infection depends on host recognition of the pathogen, hence leading to
the activation of signaling pathways controlling defense responses. A long-held belief is that …

PRR-signaling pathways: learning from microbial tactics

G Sellge, TA Kufer - Seminars in immunology, 2015 - Elsevier
Recognition of bacterial pathogens by the mammalian host relies on the induction of early
innate immune responses initiated by the activation of pattern-recognition receptors (PRRs) …

A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

J Sá-Pessoa, S López-Montesino… - Nature …, 2023 - nature.com
Bacteria can inhibit the growth of other bacteria by injecting effectors using a type VI
secretion system (T6SS). T6SS effectors can also be injected into eukaryotic cells to facilitate …