In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis
is one of the main driving factors for the progress of HF. Cardiac fibrosis was characterized …

During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate.
Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here …

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

A considerable understanding of the fundamental cellular and molecular mechanisms
underpinning healthy acute wound healing has been gleaned from studying various animal …

Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury
which restores the epidermal integrity and its barrier functions. Even under optimal healing …

It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event
during wound healing and tissue repair. The high contractile force generated by …

It is well established that tissue repair depends on stem cells and that chronic wounds
predispose to tumour formation. However, the association between stem cells, wound …

Hepatic fibrosis is a scarring process that is associated with an increased and altered
deposition of extracellular matrix in liver. At the cellular and molecular level, this progressive …

Skin wound healing is a multi stage phenomenon that requires the activation, recruitment or
activity of numerous cell types as keratinocytes, endothelial cells, fibroblast and …