Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …

BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …

High‐throughput droplet‐based digital PCR (ddPCR) is a refinement of the conventional
polymerase chain reaction (PCR)‎ methods. In ddPCR, DNA/RNA is encapsulated …

Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32)
allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in …

Over the past four decades, research on the natural history of HIV infection has described
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …

Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for
which successful therapeutic options are still being investigated. Challenges facing current …

Gene therapy is the treatment of a disease through transferring genetic material into cells of
the patients. In the recent several years, gene therapy has experienced rapid progress and …

Background A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+
leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and …

Adherence to daily oral antiretroviral therapy (ART) is a barrier to both treatment and
prevention of human immunodeficiency virus (HIV) infection. To overcome limitations of life …

CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites
of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide …