The tick-borne pathogen Powassan virus is a rare cause of encephalitis in North America
and the Russian Far East. The number of documented cases described since the discovery …

Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral
protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase …

Among mammals, bats are particularly rich in zoonotic viruses, including flaviviruses.
Certain bat species can be productively yet asymptomatically infected with viruses that …

Highlights•Detailed structural models are available for Flavivirus NS5 and NS3
proteins.•Complex structures of NS5 and NS3 with NTP and RNA substrates and regulatory …

Flaviviruses, such as dengue, Japanese encephalitis, West Nile, yellow fever, and Zika
viruses, are serious human pathogens that cause significant morbidity and mortality globally …

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that
cause significant disease in humans. Existing control measures have been ineffective at …

Flaviviruses are a genus of (+) ssRNA (positive ssRNA) enveloped viruses that replicate in
the cytoplasm of cells of diverse species from arthropods to mammals. Many are important …

Background Arboviruses are viruses transmitted to humans and other animals by the bite of
hematophagous arthropods. Infections caused by chikungunya virus (CHIKV), dengue virus …

The recent outbreak of Zika virus (ZIKV), a reemerging flavivirus, and its associated
neurological disorders, such as Guillain-Barré (GB) syndrome and microcephaly, have …