With the development of Computer-aided Diagnosis (CAD) and image scanning techniques,
Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis …

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and
molecules. Recent advances have enabled its application in cancer research and diagnosis …

In the history of science and technology, researchers have always undertaken endeavors to
enhance the degree of “directness of measurement”. With “directness of measurement”, we …

Cell mechanics is a novel label-free biomarker for indicating cell states and pathological
changes. The advent of atomic force microscopy (AFM) provides a powerful tool for …

Structural biology is currently undergoing a transformation into dynamic structural biology,
which reveals the dynamic structure of proteins during their functional activity to better …

A longstanding goal in cellular mechanobiology has been to link dynamic biomolecular
processes underpinning disease or morphogenesis to spatio-temporal changes in …

Visualization of morphological dynamics of live cells with nanometer resolution under
physiological conditions is highly desired, but challenging. It has been demonstrated that …

Single-cell analysis has been considered as a promising way to uncover the underlying
mechanisms guiding the mysteries of life activities, which considerably complements …

Highlights•I describe the unique features of high-speed AFM imaging.•I outline recent high-
speed AFM imaging of proteins and cells.•I review what types of dynamic molecular events …

We describe a tip-scan-type high-speed XYZ-nanopositioner designed for scanning ion
conductance microscopy (SICM), with a special care being devoted to the way of …