Bacterial infections and cancer
D van Elsland, J Neefjes - EMBO reports, 2018 - embopress.org
Infections are estimated to contribute to 20% of all human tumours. These are mainly caused
by viruses, which explains why a direct bacterial contribution to cancer formation has been …
by viruses, which explains why a direct bacterial contribution to cancer formation has been …
Molecular mechanisms of inflammasome activation during microbial infections
P Broz, DM Monack - Immunological reviews, 2011 - Wiley Online Library
The innate immune system plays a crucial role in the rapid recognition and elimination of
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
T Fernandes-Alnemri, JW Yu, C Juliana… - Nature …, 2010 - nature.com
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which
triggers production of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18. We …
triggers production of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18. We …
Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
Salmonella enterica is an intracellular bacterial pathogen that resides and proliferates within
a membrane-bound vacuole in epithelial cells of the gut and gallbladder. Although essential …
a membrane-bound vacuole in epithelial cells of the gut and gallbladder. Although essential …
Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle
T Starr, R Child, TD Wehrly, B Hansen, S Hwang… - Cell host & …, 2012 - cell.com
Autophagy is a cellular degradation process that can capture and eliminate intracellular
microbes by delivering them to lysosomes for destruction. However, pathogens have …
microbes by delivering them to lysosomes for destruction. However, pathogens have …
[HTML][HTML] cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
KM Storek, NA Gertsvolf, MB Ohlson… - The Journal of …, 2015 - journals.aai.org
Type I IFN production is an important host immune response against viral and bacterial
infections. However, little is known about the ligands and corresponding host receptors that …
infections. However, little is known about the ligands and corresponding host receptors that …
Brucella Modulates Secretory Trafficking via Multiple Type IV Secretion Effector Proteins
S Myeni, R Child, TW Ng, JJ Kupko III, TD Wehrly… - PLoS …, 2013 - journals.plos.org
The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV)
derived from the endoplasmic reticulum via subversion of the host cell secretory pathway …
derived from the endoplasmic reticulum via subversion of the host cell secretory pathway …
Mechanisms of Francisella tularensis intracellular pathogenesis
J Celli, TC Zahrt - Cold Spring Harbor …, 2013 - perspectivesinmedicine.cshlp.org
Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …
Bacterial recognition pathways that lead to inflammasome activation
KM Storek, DM Monack - Immunological reviews, 2015 - Wiley Online Library
Inflammasomes are multi‐protein signaling platforms that upon activation trigger the
maturation of the pro‐inflammatory cytokines, interleukin‐1β (IL‐1β) and IL‐18, and cell …
maturation of the pro‐inflammatory cytokines, interleukin‐1β (IL‐1β) and IL‐18, and cell …
Quantitative Assessment of Cytosolic Salmonella in Epithelial Cells
LA Knodler, V Nair, O Steele-Mortimer - PloS one, 2014 - journals.plos.org
Within mammalian cells, Salmonella enterica serovar Typhimurium (S. Typhimurium)
inhabits a membrane-bound vacuole known as the Salmonella-containing vacuole (SCV) …
inhabits a membrane-bound vacuole known as the Salmonella-containing vacuole (SCV) …