Infections are estimated to contribute to 20% of all human tumours. These are mainly caused
by viruses, which explains why a direct bacterial contribution to cancer formation has been …

The innate immune system plays a crucial role in the rapid recognition and elimination of
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …

Francisella tularensis, the causative agent of tularemia, infects host macrophages, which
triggers production of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18. We …

Salmonella enterica is an intracellular bacterial pathogen that resides and proliferates within
a membrane-bound vacuole in epithelial cells of the gut and gallbladder. Although essential …

Autophagy is a cellular degradation process that can capture and eliminate intracellular
microbes by delivering them to lysosomes for destruction. However, pathogens have …

Type I IFN production is an important host immune response against viral and bacterial
infections. However, little is known about the ligands and corresponding host receptors that …

The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV)
derived from the endoplasmic reticulum via subversion of the host cell secretory pathway …

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Inflammasomes are multi‐protein signaling platforms that upon activation trigger the
maturation of the pro‐inflammatory cytokines, interleukin‐1β (IL‐1β) and IL‐18, and cell …

Within mammalian cells, Salmonella enterica serovar Typhimurium (S. Typhimurium)
inhabits a membrane-bound vacuole known as the Salmonella-containing vacuole (SCV) …