Telomerase structural biology comes of age
Telomerase is an RNA–protein complex comprising telomerase reverse transcriptase, a non-
coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or …
coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or …
Unraveling the structure and biological functions of RNA triple helices
JA Brown - Wiley Interdisciplinary Reviews: RNA, 2020 - Wiley Online Library
It has been nearly 63 years since the first characterization of an RNA triple helix in vitro by
Gary Felsenfeld, David Davies, and Alexander Rich. An RNA triple helix consists of three …
Gary Felsenfeld, David Davies, and Alexander Rich. An RNA triple helix consists of three …
Structure of active human telomerase with telomere shelterin protein TPP1
Human telomerase is a RNA–protein complex that extends the 3′ end of linear
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …
Cryo-EM structure of substrate-bound human telomerase holoenzyme
THD Nguyen, J Tam, RA Wu, BJ Greber, D Toso… - Nature, 2018 - nature.com
The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …
telomeres during genome replication. Telomerase regulation has been implicated in cancer …
Architecture of human telomerase RNA
Telomerase is a unique reverse transcriptase that catalyzes the addition of telomere DNA
repeats onto the 3′ ends of linear chromosomes and plays a critical role in maintaining …
repeats onto the 3′ ends of linear chromosomes and plays a critical role in maintaining …
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions
INTRODUCTION Telomerase is a ribonucleoprotein complex that extends the telomere DNA
at the 3′ ends of linear chromosomes, thereby counteracting the loss of DNA from …
at the 3′ ends of linear chromosomes, thereby counteracting the loss of DNA from …
Poly (A) tail recognition by a viral RNA element through assembly of a triple helix
RM Mitton-Fry, SJ DeGregorio, J Wang, TA Steitz… - Science, 2010 - science.org
Kaposi's sarcoma–associated herpesvirus produces a highly abundant, nuclear noncoding
RNA, polyadenylated nuclear (PAN) RNA, which contains an element that prevents its …
RNA, polyadenylated nuclear (PAN) RNA, which contains an element that prevents its …
Structural biology of telomerase
Telomerase is a DNA polymerase that extends the 3′ ends of chromosomes by
processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) …
processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) …
Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of–1 ribosomal frameshifting
G Chen, KY Chang, MY Chou… - Proceedings of the …, 2009 - National Acad Sciences
Many viruses use programmed–1 ribosomal frameshifting to express defined ratios of
structural and enzymatic proteins. Pseudoknot structures in messenger RNAs stimulate …
structural and enzymatic proteins. Pseudoknot structures in messenger RNAs stimulate …
RNA stabilization by a poly (A) tail 3′-end binding pocket and other modes of poly (A)-RNA interaction
INTRODUCTION The polyadenylate [poly (A)] tail is one of the most conserved modifications
of RNA molecules and is an important contributor to RNA function. In conjunction with other …
of RNA molecules and is an important contributor to RNA function. In conjunction with other …