Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic
ingredient of human blood without immunogenicity and encouraged by its successful clinical …

Abstracts A major challenge in the field of nanomedicine is to transform laboratory
innovations into commercially successful clinical products. In this campaign, a variety of …

Therapeutic delivery selectively to lymph nodes has the potential to address a variety of
unmet clinical needs. However, owing to the unique structure of the lymphatics and the size …

As the most abundant plasma protein, serum albumin has been extensively studied and
employed for therapeutic applications. Despite its direct clinical use for the maintenance of …

A compact and stable bicyclic bridged ketal was developed as a ligand for the
asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency …

Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT)
activity for proliferation, therefore NAMPT represents an interesting target for the …

Ylidenenorbornadienes (YNDs), prepared by [4+ 2] cycloadditions between fulvenes and
acetylene carboxylates, react with thiol nucleophiles to yield mixtures of four to eight …

We have developed [2.2. 1] azabicyclic vinyl sulfone reagents that simultaneously enable
cysteine-selective protein modification and introduce a handle for further bioorthogonal …

Short half-life is one of the main causes of drug attrition in clinical development, which also
leads to the failure of many leading compounds and hits to become drug candidates …

Chronic wounds represent a growing clinical problem for which limited treatment strategies
exist. Defects in immune cell-mediated healing play an important role in chronic wound …