Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity
and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of …

A biofilm is an assemblage of microbial cells attached to a surface and encapsulated in an
extracellular polymeric substance (EPS) matrix. The formation of a biofilm is one of the …

Multiple drug resistance poses a significant threat to public health worldwide, with a
substantial increase in morbidity and mortality rates. Consequently, searching for novel …

Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …

The rising incidence of antibiotic resistant microorganisms urges novel antimicrobials
development with polyphenols as appealing potential therapeutics. We aimed to reveal the …

Formation of biofilm is one of the major protective mechanisms of survival of microbes under
stressed conditions. It is regulated by the quorum sensing (QS) and phenazine (phz) gene …

Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic
resistance in many bacterial pathogens, representing candidate targets for the development …

Pseudomonas aeruginosa can utilize various virulence factors necessary for host infection
and persistence. These virulence factors include pyocyanin, proteases, exotoxins, 2-heptyl-4 …

Nowadays, due to spreading antibiotic resistance among clinically relevant pathogens, the
requirement of novel therapeutic approaches is felt more than ever. One of the alternative …

The increasing resistance of bacteria to antibiotics has motivated the interest in potent
natural compounds capable of disrupting bacterial cell-to-cell communication. Column …