A megatrend challenging analytical chemistry: biosensor and chemosensor concepts ready for the internet of things

M Mayer, AJ Baeumner - Chemical reviews, 2019 - ACS Publications
The Internet of Things (IoT) is a megatrend that cuts across all scientific and engineering
disciplines and establishes an integrating technical evolution to improve production …

A critical review: Recent advances in “digital” biomolecule detection with single copy sensitivity

H Liu, Y Lei - Biosensors and Bioelectronics, 2021 - Elsevier
Detection of a single biomolecule, ranging from nucleic acids, proteins, viruses to bacteria, is
of paramount importance in various fields including biology, environment, food and …

Bipedal DNA walker based electrochemical genosensing strategy

H Chai, P Miao - Analytical chemistry, 2019 - ACS Publications
DNAs are one of the most fundamental molecules for life. Quantification of specific
sequences is of great importance for biological research and clinical diagnosis. In order to …

Portable integrated digital PCR system for the point-of-care quantification of BK virus from urine samples

L Xu, H Qu, DG Alonso, Z Yu, Y Yu, Y Shi, C Hu… - Biosensors and …, 2021 - Elsevier
This paper presents a portable integrated digital PCR (PI-dPCR) system with a self-
partitioning SlipChip (sp-SlipChip) microfluidic device for the quantitative analysis of BK …

Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies

G Gines, R Menezes, W Xiao, Y Rondelez… - Molecular Aspects of …, 2020 - Elsevier
The potential of microRNAs (miRNAs) as biomarker candidates in clinical practice for
diagnosis, prognosis and treatment response prediction, especially in liquid biopsies, has …

A single cell droplet microfluidic system for quantitative determination of food-borne pathogens

X An, P Zuo, BC Ye - Talanta, 2020 - Elsevier
Single-cell detection methods are already of great significance for many bioanalysis
applications, and droplet microfluidics technology is understood as particularly a powerful …

Microfluidic-based nucleic acid amplification systems in microbiology

L Gorgannezhad, H Stratton, NT Nguyen - Micromachines, 2019 - mdpi.com
Rapid, sensitive, and selective bacterial detection is a hot topic, because the progress in this
research area has had a broad range of applications. Novel and innovative strategies for …

Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system

W Lyu, J Zhang, Y Yu, L Xu, F Shen - Lab on a Chip, 2021 - pubs.rsc.org
Digital nucleic acid analysis (digital NAA) is an important tool for the precise quantification of
nucleic acids. Various microfluidic-based approaches for digital NAA have been developed …

Advances in improvement strategies of digital nucleic acid amplification for pathogen detection

X Xiang, Y Shang, J Zhang, Y Ding, Q Wu - TrAC Trends in Analytical …, 2022 - Elsevier
Digital nucleic acid amplification technologies (dNAATs) have become an emerging platform
for pathogen detection. It is not only suitable for the absolute quantitative analysis of target …

Wash-free, digital immunoassay in polydisperse droplets

SA Byrnes, T Huynh, TC Chang, CE Anderson… - Analytical …, 2020 - ACS Publications
Immunoassays are important for the detection of proteins to enable disease identification
and monitor treatment, but many immunoassays suffer from sensitivity limitations. The …