[HTML][HTML] PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
[HTML][HTML] Resistance mechanisms to anti-PD cancer immunotherapy
The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
[HTML][HTML] Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor
microenvironment (TME) and influence cancer hallmarks, but without systematic …
microenvironment (TME) and influence cancer hallmarks, but without systematic …
[HTML][HTML] Carbon source availability drives nutrient utilization in CD8+ T cells
How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth
The tumour microenvironment possesses mechanisms that suppress anti-tumour immunity.
Itaconate is a metabolite produced from the Krebs cycle intermediate cis-aconitate by the …
Itaconate is a metabolite produced from the Krebs cycle intermediate cis-aconitate by the …
[HTML][HTML] mTOR-mediated regulation of immune responses in cancer and tumor microenvironment
The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
A Self-Driven Bioreactor Based on Bacterium–Metal–Organic Framework Biohybrids for Boosting Chemotherapy via Cyclic Lactate Catabolism
JW Wang, QW Chen, GF Luo, ZY Han, WF Song… - ACS …, 2021 - ACS Publications
The excessive lactate in the tumor microenvironment always leads to poor therapeutic
outcomes of chemotherapy. In this study, a self-driven bioreactor (defined as SO@ MDH …
outcomes of chemotherapy. In this study, a self-driven bioreactor (defined as SO@ MDH …
[HTML][HTML] Spatial multi-omics analyses of the tumor immune microenvironment
WC Hsieh, BR Budiarto, YF Wang, CY Lin… - Journal of Biomedical …, 2022 - Springer
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …
[HTML][HTML] Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2. 1
S Chen, W Cui, Z Chi, Q Xiao, T Hu, Q Ye, K Zhu, W Yu… - Cell metabolism, 2022 - cell.com
The tumor microenvironment (TME) is a unique niche governed by constant crosstalk within
and across all intratumoral cellular compartments. In particular, intratumoral high potassium …
and across all intratumoral cellular compartments. In particular, intratumoral high potassium …
Multifunctional nanolocks with GSH as the key for synergistic ferroptosis and anti-chemotherapeutic resistance
J Zhu, X Wang, Y Su, J Shao, X Song, W Wang… - Biomaterials, 2022 - Elsevier
The emergence of chemotherapeutic resistance, which is closely related to the oxidative
stress defense induced by the imbalance of reactive oxygen species (ROS), is one of the …
stress defense induced by the imbalance of reactive oxygen species (ROS), is one of the …