Emerging roles of alternative cleavage and polyadenylation (APA) in human disease
P Dharmalingam, R Mahalingam… - Journal of Cellular …, 2022 - Wiley Online Library
In the messenger RNA (mRNA) maturation process, the 3′‐end of pre‐mRNA is cleaved
and a poly (A) sequence is added, this is an important determinant of mRNA stability and its …
and a poly (A) sequence is added, this is an important determinant of mRNA stability and its …
Alternative polyadenylation alters protein dosage by switching between intronic and 3′ UTR sites
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
Purpose Gliomas and their surrounding microenvironment constantly interact to promote
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …
Application and design considerations for 3′-end sequencing using click-chemistry
Over the past 15 years, investigations into alternative polyadenylation (APA) and its function
in cellular physiology and pathology have greatly expanded due to the emergent …
in cellular physiology and pathology have greatly expanded due to the emergent …