Application and perspectives of MALDI–TOF mass spectrometry in clinical microbiology laboratories

E Torres-Sangiao, C Leal Rodriguez, C García-Riestra - Microorganisms, 2021 - mdpi.com
Early diagnosis of severe infections requires of a rapid and reliable diagnosis to initiate
appropriate treatment, while avoiding unnecessary antimicrobial use and reducing …

MALDI-TOF mass spectrometry in the 21st century clinical microbiology laboratory

M Oviaño, B Rodríguez-Sánchez - Enfermedades infecciosas y …, 2021 - Elsevier
MALDI-TOF mass spectrometry has become a reference method for the routine identification
of bacterial isolates in clinical microbiology laboratories around the world. Its high specificity …

ICBM-OCEAN: processing ultrahigh-resolution mass spectrometry data of complex molecular mixtures

J Merder, JA Freund, U Feudel, CT Hansen… - Analytical …, 2020 - ACS Publications
Untargeted molecular analyses of complex mixtures are relevant for many fields of research,
including geochemistry, pharmacology, and medicine. Ultrahigh-resolution mass …

Metabolomic tools used in marine natural product drug discovery

KA Stuart, K Welsh, MC Walker… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: The marine environment is a very promising resource for natural product
research, with many of these reaching the market as new drugs, especially in the field of …

Single-cell classification using mass spectrometry through interpretable machine learning

YR Xie, DC Castro, SE Bell, SS Rubakhin… - Analytical …, 2020 - ACS Publications
The brain consists of organized ensembles of cells that exhibit distinct morphologies,
cellular connectivity, and dynamic biochemistries that control the executive functions of an …

[HTML][HTML] Volatile compounds and protein profiles analyses of fermented cocoa beans and chocolates from different hybrids cultivated in Brazil

IM da Veiga Moreira, L de Figueiredo Vilela… - Food Research …, 2018 - Elsevier
Cocoa beans from different geographical and genetic origins show distinct fermentation
dynamics which result in different chocolate qualities. In order to understand the effects of …

Applications of artificial intelligence in clinical microbiology diagnostic testing

KP Smith, H Wang, TJS Durant, BA Mathison… - Clinical Microbiology …, 2020 - Elsevier
The use of artificial intelligence (AI) computer software to interpret data has become part of
our everyday lives, and these AI algorithms are becoming part of our everyday laboratory …

Detection of carbapenem-resistant Klebsiella pneumoniae on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using …

TS Huang, SSJ Lee, CC Lee, FC Chang - PLoS One, 2020 - journals.plos.org
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as a
significant pathogen causing healthcare-associated infections. Matrix‐assisted laser …

Novel site-specific PEGylated L-asparaginase

GP Meneguetti, JHPM Santos, KMT Obreque… - PLoS …, 2019 - journals.plos.org
L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its
PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL) …

[HTML][HTML] Deep metric learning for the classification of MALDI-TOF spectral signatures from multiple species of neotropical disease vectors

F Merchan, K Contreras, RA Gittens, JR Loaiza… - Artificial Intelligence in …, 2023 - Elsevier
Deep Learning techniques have significant advantages for mass spectral classification, such
as parallelized signal correction and feature extraction. Deep Metric Learning models …